By National Council on Radiation Protection and Measurements
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Extra resources for The Relative Biological Effectiveness of Radiations of Different Quality: Recommendations of the National Council on Radiation Protection and Measure (N C R P Report)
1974) Matsubara et al. (1988)" Fabry et al. (1985)' Lloyd et al. (1976) Fabry et al. (1985P Muramatau and Mamy(1977) Bajaktarovic et al. 03 Zhou et al. 64 Sevankaev et al. 78 Lloyd et a1. 12 Bauchinger et d. 0 Lloyd et al. , (1982). bInclude~ centric rings. 'Data from scoring first division m e t a p h a s or from cultures with l e s ~ than five percent second division metaphasee. 5). Linear dose response relationships have also been observed after exposures of mammalian cells to various heavy ions and a particle emitting radionuclides.
1983)b 250 kVp 0 . 31 Lloyd et al. 20 ? 11 Leonard et al. 6 - Kucerova et al. (1972). 74 - Vulpis et al. 14 Fabry et al. 22 Lloyd et al. Includes centric rings. bData from scoring first division metaphases. As with x rays, narrower ranges of values for a and flcoefficients are observed when inter-laboratory comparisons are restricted to data h m studies that employed BrdU methodology. , as would be expected if aberrations that result from inter-track lesions are independent of LET. However, comparisons of estimates of a generally show that hard x rays are more efficient than gamma rays in inducing "one t r a c k aberrations, as would be predicted if the proportion of exchanges resulting from intra-track effects were LET dependent.
1) For all measured endpoints, the dose response relationship is best described by the linear quadratic model when cells receive acute exposures to high dose rate, low-LET radiation. (2) Reduction in dose rate results in a diminution of cytogenetic effects &r exposure to a given dose of low-LET radiation. At very low levels of dose and a t low dose rates, chromosome exchange induction varies as a linear function of dose. (3) For all high-LET radiations, cytogenetic exchange induction varies predominantly as a linear function of dose, and is doserate independent.